Selection of chemical analogues: replacement of dangerous substances, alternative research methods


Substances with certain hazardous properties can be hazardous to human health

and / or the environment.

Replacing hazardous chemicals with safer ones can bring significant benefits to your company, the environment, and health of workers and consumers.

What substances are candidates for substitution?

  • Substances included in the PBT- and vPvB-lists
  • Endocrine-disrupting chemicals
  • Carcinogens
  • Mutagens
  • Reproductive toxicants
  • Respiratory sensitizers

Reasons for the search for analogues

of hazardous chemicals

  • Improving the environmental footprint of their products or manufacturing processes
  • Timely responding to client demands or legal requirements
  • providing a better technical functionality


Improving the efficiency
of the manufacturing process

Savings in
regulatory costs


Doing the
right thing


 Traditional toxicity and ecotoxicity testing methods are resource-intensive.  With the advent of legislation such as REACH and TR EAEU 041/2017 that mandates the development of comprehensive toxicity information for large numbers of chemicals, it is clear that current methods cannot keep pace with the demand for information. 

What is Read-Across?


  • It’s a technique for predicting endpoint information for one substance (target substance), by using data from the same endpoint from (an)other substance(s) (source substance(s)).
  • Category formation, grouping and read across methods are broadly applicable in toxicological assessments and may be used to fill data gaps for chemical safety assessment and regulatory decisions

Why reading across?


  • To avoid additional animal testing
  • Find replacements for traditional, resource-intensive toxicity and ecotoxicity testing
  • To cover more substances within one safety assessment
  • To use human data, if available, for one compound but not possible to produce for another

Application of read-across in regulatory context

  • 75% of all registration dossiers under REACH include read-across or categorisation reasoning
  • Read-across methods are supported by the large database of toxicology studies that have been conducted over the past 50+ years
  • The use of read across predictions data is supported by EAEU TR 041/2017 "On the safety of chemical products"